Boeblingen, March 2026 - Wörwag Pharma is pleased to announce the publication of its proprietary clinical study in the peer-reviewed journal Food & Nutrition Research. The investigation focuses on optimizing the bioavailability of milk thistle extract and underscores the company’s scientific commitment to the development of advanced formulations.
Wörwag Pharma: Clinical Bioavailability Study Published
The human clinical trial was conducted in collaboration with BioTeSys GmbH in Esslingen, Germany. In a randomized, cross-over study involving 18 healthy adults, researchers investigated how different formulation approaches affect the absorption of silybin - the central component of milk thistle extract. The study compared two formulations containing identical amounts of the extract over a 24-hour period.
The published data demonstrate a significantly enhanced absorption of silybin, reaching 8.6 fold higher levels ,using the combination of silymarin with krill oilcompared to a standard formulation. In addition, the formula contains the nutritionally important omega-3 fatty acids and choline. By publishing these results, Wörwag Pharma contributes to pharmacological research and expands the scientific evidence base regarding bioavailability-optimized silymarin formulations.
"The publication in a recognized scientific journal is a consistent step in our strategy to drive the development of our preparations on a solid scientific foundation," the company stated.
Publication Reference:
Engelhart-Jentzsch, K., Gantenbein, A.-K., Schön, C., Wilhelm, M., Stadelmayer, L., Pross, L., Kaiser-Zimmermann, T., Guerrero, G., Jaghutriz, B. A., & Reule, C. (2026). Enhanced bioavailability of a krill oil-based milk thistle extract formulation: in vitro and human studies. Food & Nutrition Research, 70.